| Movie | Role |
|---|---|
| Sherlock Holmes (2009) | Irene Adler |
| Mean Girls (2004) | Regina George |
| The Notebook (2004) | Allie Hamilton, Allison "Allie" Hamilton |
| Red Eye (2005) | Lisa Reisert |
| The Hot Chick (2002) | Jessica Spencer / Clive Maxtone |
| About Time (2013) | Mary |
| A Most Wanted Man (2014) | Annabel Richter |
| Doctor Strange (2016) | Dr. Christine Palmer |
| Spotlight (2015) | Sacha Pfeiffer |
| Game Night (2018) | Annie |
| Doctor Strange in the Multiverse of Madness (2022) | Dr. Christine Palmer |
| Sherlock Holmes: A Game of Shadows (2011) | Irene Adler |
| Midnight in Paris (2011) | Inez |
| Wedding Crashers (2005) | Claire Cleary |