| Movie | Role |
|---|---|
| Sky High (2005) | Gwen Grayson / Royal Pain |
| Live Free or Die Hard (2007) | Lucy McClane |
| Scott Pilgrim vs. the World (2010) | Ramona Flowers |
| Kill the Messenger (2014) | Anna Simons |
| 10 Cloverfield Lane (2016) | Michelle |
| Swiss Army Man (2016) | Sarah |
| Birds of Prey (and the Fantabulous Emancipation of One Harley Quinn) (2020) | Helena Bertinelli / Huntress |
| Kate (2021) | Kate |
| Abraham Lincoln: Vampire Hunter (2012) | Mary Todd Lincoln |