| Movie | Role |
|---|---|
| Mask (1985) | Diana |
| October Sky (1999) | Miss Riley |
| Citizen Ruth (1996) | Ruth Stoops |
| Inland Empire (2006) | Nikki Grace / Susan Blue, Producer |
| Fat Man and Little Boy (1989) | Kathleen Robinson |
| The Founder (2016) | Ethel Kroc |
| Jurassic Park (1993) | Dr. Ellie Sattler |
| Little Women (2019) | Margaret "Marmee" March |
| Certain Women (2016) | Laura Wells |
| Wild at Heart (1990) | Lula Fortune |
| Marriage Story (2019) | Nora Fanshaw |
| Jurassic World Dominion (2022) | Dr. Ellie Sattler |
| The Master (2012) | Helen |
| Blue Velvet (1986) | Sandy Williams |