| Movie | Role |
|---|---|
| Pineapple Express (2008) | Saul Silver |
| This Is the End (2013) | James Franco |
| Spring Breakers (2013) | Alien |
| Sausage Party (2016) | Druggie (voice) |
| The Interview (2014) | Dave Skylark |
| The Disaster Artist (2017) | Director, Producer, Tommy / "Johnny", Tommy Wiseau |
| 127 Hours (2010) | Aron Ralston |
| The Ballad of Buster Scruggs (2018) | Cowboy (segment "Near Algodones") |
| Spider-Man (2002) | Harry Osborn |
| Spider-Man 2 (2004) | Harry Osborn |
| Spider-Man 3 (2007) | Harry Osborn / New Goblin, New Goblin / Harry Osborn |
| Rise of the Planet of the Apes (2011) | Will Rodman |